Mason S T, Fibiger H C
Psychopharmacology (Berl). 1979 Nov;66(2):179-82. doi: 10.1007/BF00427627.
Neither acquisition learning nor 24-h retention was significantly altered by 6-hydroxydopamine intracerebral injections which depleted forebrain noradrenaline (NA) to less than 5% of control values. The absence of passive avoidance impairment cannot be ascribed to functional recovery following the lesion (indicated by testing 24 h post-operation) and by using the F-344 strain of rat which does not show denervation supersensitivity as measured by NA-sensitive adenylate cyclase. Nonassociative freezing to electric footshock, changed by the injections, resulted in slower acquisition at a footshock level 4 mA, but not at 1 mA.
脑室内注射6-羟基多巴胺使前脑去甲肾上腺素（NA）耗竭至对照值的5%以下，习得性学习和24小时记忆均未受到显著影响。被动回避障碍的缺失不能归因于损伤后的功能恢复（通过术后24小时测试表明），也不能归因于使用F-344品系大鼠，该品系大鼠未表现出如通过对NA敏感的腺苷酸环化酶测量的去神经超敏反应。注射改变了对足部电击的非联想性僵住反应，在4毫安足部电击水平下导致习得变慢，但在1毫安时则没有。
