Archer T, Mohammed A K, Danysz W, Järbe T U, Jonsson G
Behav Brain Res. 1986 Apr;20(1):47-56. doi: 10.1016/0166-4328(86)90100-2.
In order to investigate the effect of noradrenaline (NA) depletion upon an associative learning phenomenon, sensory preconditioning, rats were inflicted with either 6-hydroxydopamine-induced lesions of the dorsal noradrenergic bundle (DNAB) or the locus coeruleus (LC), or with systemic injections of the NA neurotoxin, N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4). Using appropriate controls (the UP groups) sensory preconditioning was demonstrated clearly in the non-lesion conditions (Sham or saline), but was blocked or strongly attenuated in the DNAB and DSP4 conditions. LC lesions did not affect sensory preconditioning. These findings suggest that the loss of central NA may cause some disruption of some aspects of complex associative learning. The role of NA in sensory preconditioning may be relevant to current notions of NA function.
为了研究去甲肾上腺素（NA）耗竭对一种联想学习现象——感觉预适应的影响，对大鼠施加了以下处理：通过6-羟基多巴胺诱导损毁背侧去甲肾上腺素能束（DNAB）或蓝斑（LC），或者全身注射NA神经毒素N-(2-氯乙基)-N-乙基-2-溴苄胺（DSP4）。使用适当的对照组（UP组），在非损毁条件下（假手术或生理盐水注射）能清楚地证明感觉预适应，但在DNAB和DSP4处理条件下，感觉预适应被阻断或显著减弱。LC损毁不影响感觉预适应。这些发现表明，中枢NA的缺失可能会对复杂联想学习的某些方面造成一些干扰。NA在感觉预适应中的作用可能与当前关于NA功能的概念相关。
