Sheridan G W, Matsen F A
Clin Orthop Relat Res. 1975 Nov-Dec(113):36-42. doi: 10.1097/00003086-197511000-00006.
An animal model of the compartmental syndrome is presented to study the effect of elevated intracompartmental pressure on muscle histology and nutrient blood flow. Latex balloons were inserted into the anterior compartment of rabbits and the pressure within them controlled by an adjustable water column. Nutrient blood flow to the muscles of the compartment was determined by an Rb86 isotope dilution technique and showed a progressive decline with intracompartmental pressures over 50 mm Hg. At 80 mm Hg, flow was but 5 per cent of control values. An inflammatory necrosis was noted when a pressure of 60 mm Hg was exerted for 24 hours. At higher pressures an ischemic necrosis without inflammation was observed.
本文提出一种骨筋膜室综合征动物模型，以研究骨筋膜室内压力升高对肌肉组织学和营养血流的影响。将乳胶球囊插入兔的前骨筋膜室，并通过可调节的水柱控制球囊内压力。采用Rb86同位素稀释技术测定骨筋膜室肌肉的营养血流，结果显示，当骨筋膜室内压力超过50mmHg时，血流呈逐渐下降趋势。当压力达到80mmHg时，血流仅为对照值的5%。当施加60mmHg的压力持续24小时时，可见炎性坏死。在更高的压力下，则观察到无炎症的缺血性坏死。
