Wubbels R J, Sondag H N P M, van Marle J, de Jong H A A
Vestibular Department ENT, Academic Medical Center, University of Amsterdam, P.O.Box 22660, 1100 DD Amsterdam, The Netherlands.
Brain Res Bull. 2002 Mar 15;57(5):677-82. doi: 10.1016/s0361-9230(01)00778-x.
The effect of prolonged exposure to hypergravity on the morphology of vestibular epithelia of rats was investigated. At the age of 1 month, i.e., when vestibular end organs are fully maturated, three rats were transferred to a hypergravity environment of 2.5 g inside a large radius centrifuge. After 9 months, vestibular epithelia of these animals and of three control animals were immunohistochemically labeled for actin and tubulin. The apical cross-sectional area of epithelial cells of hypergravity exposed rats appeared to be smaller in all end organs. Area reduction was 1.9% in the saccule (not significant), 5.0% in the utricle (p < 0.005), and 11.6% in the crista (p<<0.001). No indications for a deterioration of vestibular functioning were observed.
研究了长时间暴露于超重环境对大鼠前庭上皮形态的影响。在1月龄时，即前庭终器完全成熟时，将3只大鼠转移至大半径离心机内2.5g的超重环境中。9个月后，对这些动物和3只对照动物的前庭上皮进行肌动蛋白和微管蛋白的免疫组织化学标记。在所有终器中，暴露于超重环境的大鼠上皮细胞的顶端横截面积似乎较小。球囊的面积减少了1.9%（无统计学意义），椭圆囊减少了5.0%（p<0.005），嵴减少了11.6%（p<<0.001）。未观察到前庭功能恶化的迹象。
