Tracey J A, Cassidy N, Casey P B, Ali I
The National Poisons Information Centre, Beaumont Hospital, Dublin, Ireland.
Ir Med J. 2002 Jan;95(1):23-4.
Bupropion is a monocyclic antidepressant structurally related to amphetamine. Zyban, a sustained-release formulation of bupropion hydrochloride, was recently released in Ireland, as a smoking cessation aid. In the initial 6 months since it's introduction, 12 overdose cases have been reported to The National Poisons Information Centre. 8 patients developed symptoms of toxicity. Common features included tachycardia, drowsiness, hallucinations and convulsions. Two patients developed severe cardiac arrhythmias, including one patient who was resuscitated following a cardiac arrest. All patients recovered without sequelae. We report a case of a 31 year old female who required admission to the Intensive Care Unit for ventilation and full supportive therapy, following ingestion of 13.5g bupropion. Recurrent seizures were treated with diazepam and broad complex tachycardia was successfully treated with adenosine. Zyban caused significant neurological and cardiovascular toxicity in overdose. The potential toxic effects should be considered when prescribing it as a smoking cessation aid.
安非他酮是一种结构上与苯丙胺相关的单环抗抑郁药。盐酸安非他酮缓释片（Zyban）最近在爱尔兰上市，作为一种戒烟辅助药物。自其上市后的最初6个月里，国家毒物信息中心共收到12例过量服用的报告。8名患者出现了中毒症状。常见症状包括心动过速、嗜睡、幻觉和抽搐。两名患者出现严重心律失常，其中一名患者心脏骤停后经复苏成功。所有患者均康复且无后遗症。我们报告一例31岁女性，在服用13.5克安非他酮后因需要通气和全面支持治疗而入住重症监护病房。反复癫痫发作使用地西泮治疗，宽QRS波心动过速使用腺苷成功治疗。安非他酮过量会导致严重的神经和心血管毒性。在将其作为戒烟辅助药物开处方时，应考虑其潜在的毒性作用。
