Hosono A
Faculty of Agriculture, University of Riau, Indonesia.
J Dairy Res. 2001 Nov;68(4):617-24. doi: 10.1017/s0022029901005179.
The effects of administration of Lactobacillus gasseri SBT0270 on serum lipids and bile acids, faecal bile acids and microflora were estimated in hypercholesterolemic rats. An effective dose of strain SBT0270 to exert its hypocholesterolemic effect was 10(9) viable cells/d. The dose of 10(9) cells/d did not affect the faecal coliform counts, but the number of faecal lactobacilli in rats fed this dose was significantly higher than that in the control group observed at the end of feeding period. Hypocholesterolemic effect of Lb. gasseri SBT0270 was attributed to its ability to suppress the reabsorption of bile acids into the enterohepatic circulation and to enhance the excretion of acidic steroids in faeces of hypercholesterolemic rats.
在高胆固醇血症大鼠中评估了给予加氏乳杆菌SBT0270对血清脂质和胆汁酸、粪便胆汁酸及微生物群的影响。发挥降胆固醇作用的SBT0270菌株有效剂量为10⁹个活细胞/天。10⁹个细胞/天的剂量不影响粪便大肠菌群计数，但在喂食期结束时观察到，给予该剂量的大鼠粪便中乳酸杆菌数量显著高于对照组。加氏乳杆菌SBT0270的降胆固醇作用归因于其抑制胆汁酸重吸收进入肠肝循环以及增强高胆固醇血症大鼠粪便中酸性类固醇排泄的能力。
