Mason D Y, André P, Bensussan A, Buckley C, Civin C, Clark E, de Haas M, Goyert S, Hadam M, Hart D, Horejsí V, Meuer S, Morissey J, Schwartz-Albiez R, Shaw S, Simmons D, Uguccioni M, van der Schoot E, Viver E, Zola H
Haematology Department, Nuffield Dept. of Clinical Laboratory Sciences, University of Oxford, Rm. 4734 John Radcliffe Hospital, Oxford OX3 9DU, UK.
Tissue Antigens. 2001 Dec;58(6):425-30. doi: 10.1034/j.1399-0039.2001.580614.x.
The most recent Human Leucocyte Differentiation Antigen Workshop ("HLDA7") took place in 2000 in Harrogate, UK and the proceedings are about to be published (Leucocyte Typing VII). New Sections were introduced in this Workship (Dendritic cells, Stem/progenitor cells, Erythroid cells and Carbohydrate Structures) and monoclonal antibodies were selected for which at least some molecular data were already available (to avoid "blind" screening of reagents against known specificities). A total of more than 80 new CD specificities were established (previously the average was less than 30 new CD specificities per Workshop) and these are listed in this article. There is already evidence for the existence of many new leucocyte surface molecules for study at the next HLDA Workshop (in Adelaide in 2004), and we have listed in this article a number of such potential CD candidates (identified following the production of monoclonal antibodies or via gene cloning). There are also today an increasing number of lineage- and/or stage-restricted leucocyte-associated molecules localised within the cell cytoplasm (or nucleus): they will certainly prove of intense in the future for many laboratories studying human haematopoietic cells (regardless of whether a new "intracellular CD" categorisation scheme is devised for such molecules).
最近一次人类白细胞分化抗原研讨会(“HLDA7”)于2000年在英国哈罗盖特举行,会议论文集即将出版(《白细胞分型VII》)。本次研讨会引入了新的章节(树突状细胞、干/祖细胞、红细胞和碳水化合物结构),并选择了至少已有一些分子数据的单克隆抗体(以避免针对已知特异性对试剂进行“盲目”筛选)。总共确定了80多种新的CD特异性(以前每次研讨会平均确定的新CD特异性少于30种),本文列出了这些特异性。已有证据表明存在许多新的白细胞表面分子,可供下一次HLDA研讨会(2004年在阿德莱德举行)研究,我们在本文中列出了一些此类潜在的CD候选物(在产生单克隆抗体或通过基因克隆后确定)。如今,位于细胞质(或细胞核)内的谱系和/或阶段受限的白细胞相关分子也越来越多:对于许多研究人类造血细胞的实验室来说,它们在未来肯定会被证明具有重要意义(无论是否为这类分子设计新的“细胞内CD”分类方案)。