Maraha B, Peeters M F, van Aken B E, den Heijer M
Reg Lab Medical Microbiology, Albert Schweitzer Hospital, Dordrecht, Netherlands.
Diagn Microbiol Infect Dis. 2002 Mar;42(3):153-7. doi: 10.1016/s0732-8893(01)00347-9.
Inflammatory mediators are involved in activation of the coagulation system, and elevated plasma concentrations of IL-6 and IL-8 are associated with an increased risk of venous thrombosis. Using serologic and molecular biologic tests, we investigated in a case-control study on patients with recurrent venous thrombosis the association between Chlamydia (C) pneumoniae and venous thrombosis and we evaluated the relation between C. pneumoniae serology and the cytokines IL-6 and IL-8. The presence of C. pneumoniae antibody titers > or = 1:16 was not associated with an increased risk of venous thrombosis (odds ratio 0.8 95% CI, 0.4-1.7). Circulating C. pneumoniae-DNA was detected in only one patient and two control subjects. IgG antibody titers against C. pneumoniae were not correlated with the concentrations of IL-6 and IL-8. These results indicate that the inflammatory process shown in patients with venous thrombosis is not related to C. pneumoniae.
炎症介质参与凝血系统的激活，血浆中白细胞介素-6（IL-6）和白细胞介素-8（IL-8）浓度升高与静脉血栓形成风险增加相关。我们通过血清学和分子生物学检测，在一项针对复发性静脉血栓形成患者的病例对照研究中，调查了肺炎衣原体（C）与静脉血栓形成之间的关联，并评估了肺炎衣原体血清学与细胞因子IL-6和IL-8之间的关系。肺炎衣原体抗体滴度≥1:16与静脉血栓形成风险增加无关（比值比0.8，95%可信区间，0.4 - 1.7）。仅在一名患者和两名对照受试者中检测到循环中的肺炎衣原体DNA。针对肺炎衣原体的IgG抗体滴度与IL-6和IL-8的浓度无关。这些结果表明，静脉血栓形成患者中显示的炎症过程与肺炎衣原体无关。
