Emmerich Joseph
Service de Médecine Vasculaire et HTA, Centre Claude Bernard de recherche sur les maladies vasculaires, INSERM U428, University Paris 5, Paris, France.
Pathophysiol Haemost Thromb. 2002 Sep-Dec;32(5-6):346-8. doi: 10.1159/000073596.
Chlamydia pneumoniae infection has been linked to atherosclerosis, but a possible relationship with venous thromboembolism (VTE) had not been sought. We determined circulating anti-C. pneumoniae antibody levels in patients with VTE. Fifty-four percent of the cases and 15.9% of the controls had specific IgG titers of at least 256 (p<0.0001). The crude odds ratio for VTE was 6.2 (95% CI, 3.8-10.1), and rose to 7.7 (4.5-13.2) after excluding subjects carrying the factor V Arg 506 Gln or factor II G 20210 A mutations. Other studies did not confirm such an association or found a lower odds ratio. This association remains to be confirmed in other case-control or prospective studies.
肺炎衣原体感染与动脉粥样硬化有关，但尚未探究其与静脉血栓栓塞（VTE）之间可能存在的关系。我们测定了VTE患者体内循环抗肺炎衣原体抗体水平。54%的病例和15.9%的对照者特异性IgG滴度至少为256（p<0.0001）。VTE的粗比值比为6.2（95%可信区间，3.8 - 10.1），在排除携带因子V Arg 506 Gln或因子II G 20210 A突变的受试者后升至7.7（4.5 - 13.2）。其他研究未证实这种关联或发现较低的比值比。这种关联仍有待其他病例对照研究或前瞻性研究加以证实。
