Ishiwata Kiichi, Ogi Nobuo, Hayakawa Nobutaka, Umegaki Hiroyuki, Nagaoka Tsukasa, Oda Keiichi, Toyama Hinako, Endo Kazutoyo, Tanaka Akira, Senda Michio
Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1-1 Naka-cho, Itabashi-ku, 172-0022, Tokyo, Japan.
Nucl Med Biol. 2002 Apr;29(3):307-16. doi: 10.1016/s0969-8051(01)00307-9.
With [11C]raclopride,[11C]nemonapride and [11C]N-methylspiperone, degeneration of dopamine D2-like receptors in the unilaterally quinolinic acid-lesioned rats was evaluated by positron emission tomography (PET) and ex vivo and in vitro autoradiography. PET showed a decreased uptake of [11C]raclopride in the lesioned striatum, but an increased uptake of [11C]nemonapride and [11C]N-methylspiperone despite a decreased binding in vitro. Ex vivo autoradiography showed an increased accumulation of the three ligands in the cortical region overlying the injured striatum, probably enlarging PET signals. PET has the limited potential for evaluating the receptor degeneration in the present animal model.
利用[11C]雷氯必利、[11C]奈莫必利和[11C]N-甲基螺哌啶，通过正电子发射断层扫描（PET）以及离体和体外放射自显影技术，对单侧喹啉酸损伤大鼠中多巴胺D2样受体的退化情况进行了评估。PET显示，在损伤的纹状体中[11C]雷氯必利摄取减少，但[11C]奈莫必利和[11C]N-甲基螺哌啶摄取增加，尽管体外结合减少。离体放射自显影显示，在损伤纹状体上方的皮质区域，这三种配体的积累增加，这可能会扩大PET信号。在当前动物模型中，PET评估受体退化的潜力有限。
