Shan'gina O V, Markarian A G, Bul'bulian M A, Zaridze D G
Med Tr Prom Ekol. 2002(2):17-20.
The authors conducted 2 independent cohort studies on epidemiology of malignancies among workers contacting chloroprene. The first study covered morbidity and mortality with malignancies among workers engaged into polychloroprene resins production in Erevan; the second study--mortality with malignancies among Moscow shoe makers who contacted polychloroprene glues and latex. The findings are reliably higher risk of morbidity and mortality with hepatic cancer, dose--effect dependence between chloroprene exposure and occurrence of and mortality with hepatic cancer.
作者对接触氯丁二烯的工人进行了两项关于恶性肿瘤流行病学的独立队列研究。第一项研究涵盖了埃里温从事聚氯丁二烯树脂生产的工人中恶性肿瘤的发病率和死亡率；第二项研究是关于接触氯丁二烯胶水和乳胶的莫斯科制鞋工人中恶性肿瘤的死亡率。研究结果表明，患肝癌的发病风险和死亡风险确实更高，氯丁二烯暴露与肝癌的发生及死亡之间存在剂量-效应依赖关系。
