Shan'gina O V, Bul'bulian M A, Nikolaeva G M, Mironov A I
Med Tr Prom Ekol. 1998(1):8-12.
Epidemiologic study of occupational cancer covered a cohort of shoe production workers exposed to chloroprene. The cohort consists of 5058 examinees having length of service over 2 years and subjected to follow-up for 15 years. The total person-years equaled 75,000. The examinees demonstrated higher mortality with liver cancer, leukoses, pancreatic carcinoma, malignancies of central nervous system, renal cancer. The study first revealed unusual but significant risk of mortality with malignancies of mediastinum and heart (ICD-12 code is 164). The study defined a "dose-effect" correlation between exposure to chloroprene and death with liver cancer.
职业性癌症的流行病学研究涵盖了一组接触氯丁二烯的制鞋工人。该队列由5058名工龄超过2年并接受了15年随访的受试者组成。总人年数为75000。受试者在肝癌、白血病、胰腺癌、中枢神经系统恶性肿瘤、肾癌方面表现出较高的死亡率。该研究首次揭示了纵隔和心脏恶性肿瘤（国际疾病分类第12版代码为164）存在异常但显著的死亡风险。该研究确定了接触氯丁二烯与肝癌死亡之间的“剂量-效应”相关性。
