阿尔茨海默病研究进入“新周期”：意义何在？
Alzheimer's disease research enters a "new cycle": how significant?
作者信息
Copani A, Sortino M A, Nicoletti F, Giuffrida Stella A M
机构信息
Department of Chemical Sciences, Section of Biochemistry and Molecular Biology, University of Catania, Italy.
出版信息
Neurochem Res. 2002 Feb;27(1-2):173-6. doi: 10.1023/a:1014879311761.
PMID:11930909
Abstract
Recent evidence suggests a link between the aberrant re-expression of cell cycle proteins in adult neurons of the Alzheimer's disease brain and the process of apoptotic degeneration. Here we will discuss this unexpected phenomenon as related to the mechanisms of beta-amyloid toxicity, and its significance for therapeutic possibilities.
摘要
最近的证据表明，阿尔茨海默病大脑成年神经元中细胞周期蛋白的异常重新表达与凋亡性退变过程之间存在联系。在此，我们将讨论这一意外现象与β-淀粉样蛋白毒性机制的相关性及其对治疗可能性的意义。
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