Poston W S C, Haddock C K, Spertus J, Catanese D M, Pavlik V N, Hyman D J, Hanis C L, Forevt J P
Mid America Heart Institute and the University of Missouri-Kansas City, 64110, USA.
Eat Weight Disord. 2002 Mar;7(1):68-71. doi: 10.1007/BF03354432.
The G-protein beta3 subunit 825 TT genotype has been associated with obesity and hypertension. We examined the interaction between the G-protein TT genotype, physical activity and body mass index (BMI) in a cross-sectional study of African immigrants and African Americans. The genotype frequencies were 6.3% CC, 37.7% CT, and 56% TT. After adjusting for potential confounders, BMI was found to be significantly higher in the sedentary than in the physically active participants (p=0.045). There was no statistically significant effect for genotype (p=0.215) or the interaction between genotype and the level of physical activity (p=0.219). However, the individuals with the CC or CT genotype who were physically active had substantially lower BMIs (M+/-SE) (i.e., 25.74+/-2.02) than any of the other groups: sedentary CC + CT (30.58+/-1.03), sedentary TT (30.65+/-1.00) or active TT (29.43+/-1.65). Because of the low statistical power of this study, further research is needed to confirm these findings and to explore potential gene-environment/lifestyle interactions.
G蛋白β3亚基825 TT基因型与肥胖症和高血压有关。在一项针对非洲移民和非裔美国人的横断面研究中，我们研究了G蛋白TT基因型、身体活动与体重指数（BMI）之间的相互作用。基因型频率分别为：CC占6.3%，CT占37.7%，TT占56%。在对潜在混杂因素进行校正后，发现久坐不动的参与者的BMI显著高于有身体活动的参与者（p = 0.045）。基因型（p = 0.215）以及基因型与身体活动水平之间的相互作用（p = 0.219）均无统计学显著效应。然而，有身体活动的CC或CT基因型个体的BMI（均值±标准误）（即25.74±2.02）显著低于其他任何组：久坐不动的CC + CT组（30.58±1.03）、久坐不动的TT组（30.65±1.00）或有身体活动的TT组（29.43±1.65）。由于本研究的统计效力较低，需要进一步研究以证实这些发现并探索潜在的基因-环境/生活方式相互作用。
