Siffert W, Naber C, Walla M, Ritz E
Institut für Pharmakologie, Universitätsklinikum Essen, Germany. winfried.siffert@uni-essen de.
J Hypertens. 1999 Aug;17(8):1095-8. doi: 10.1097/00004872-199917080-00008.
The 825T allele of the G protein beta3 subunit is associated with hypertension in Caucasians. To generate a novel hypothesis regarding the underlying mechanisms, we examined for a potential association of the 825T allele with obesity in hypertension.
We genotyped 197 hypertensive individuals (104 men, 93 women; mean age 54 years) recruited from the general population in the Heidelberg (Germany) area. Data acquisition included age at first diagnosis of hypertension, body weight and height, actual treated blood pressure values, and history of stroke and/or myocardial infarction (cardiovascular events).
The 825T allele was significantly (P = 0.02) associated with body mass index (BMI), mean values being 28.6+/-4.1, 27.0+/-3.1, and 26.1+/-3.8 kg/m2 for TT, TC, and CC respectively, which persisted after correction for sex and age. The 825T allele frequency was 23.8, 31.4 and 40.0% in individuals with normal weight (BMI <24.9 kg/m2), overweight (BMI 25.0-29.9 kg/m2), and obesity (BMI >29.9 kg/m2), respectively. Odds ratio for obesity versus normal weight was 3.9 [95% confidence interval (CI) 1.1-14.3; P = 0.03] for TT/CC and 1.8 (95% CI 0.7-4.6; P = 0.18) for TC/CC. BMI and age, but not genotype were significantly correlated with cardiovascular events as determined by logistic regression analysis.
The findings suggest an association between obesity and the 825T allele, a genetic marker for enhanced G protein reactivity, in hypertensive individuals.
G蛋白β3亚基的825T等位基因与高加索人的高血压相关。为了提出关于潜在机制的新假设，我们研究了825T等位基因与高血压患者肥胖之间的潜在关联。
我们对从德国海德堡地区普通人群中招募的197名高血压患者（104名男性，93名女性；平均年龄54岁）进行了基因分型。数据采集包括首次诊断高血压时的年龄、体重和身高、实际治疗的血压值以及中风和/或心肌梗死（心血管事件）病史。
825T等位基因与体重指数（BMI）显著相关（P = 0.02），TT、TC和CC基因型的BMI平均值分别为28.6±4.1、27.0±3.1和26.1±3.8 kg/m²，在对性别和年龄进行校正后该关联依然存在。体重正常（BMI<24.9 kg/m²）、超重（BMI 25.0 - 29.9 kg/m²）和肥胖（BMI>29.9 kg/m²）个体的825T等位基因频率分别为23.8%、31.4%和40.0%。TT/CC基因型肥胖与体重正常个体的比值比为3.9 [95%置信区间（CI）1.1 - 14.3；P = 0.03]，TC/CC基因型为1.8（95% CI 0.7 - 4.6；P = 0.18）。通过逻辑回归分析确定，BMI和年龄与心血管事件显著相关，但基因型与心血管事件无显著相关性。
研究结果表明，在高血压个体中，肥胖与825T等位基因（一种增强G蛋白反应性的遗传标记）之间存在关联。
