Stachowiak R, Bielecki J
Department of Applied Microbiology, Institute of Microbiology, Warsaw University, Poland.
Acta Microbiol Pol. 2001;50(3-4):243-50.
The life cycle of Listeria monocytogenes strongly depends on cytolysin which facilitates the pathogen's escape from the endosome. This process is very ineffective in the absence of phospholipases. In this study we investigated the molecular mechanism of cooperation between hemolysin and phospholipases. We propose a model involving interactions between proteins that increase the affinity of cytolysins for the membrane as well direct enzymatic enhancement of lysis.
单核细胞增生李斯特菌的生命周期在很大程度上依赖于溶细胞素，溶细胞素有助于病原体从内涵体中逃逸。在没有磷脂酶的情况下，这个过程效率很低。在本研究中，我们调查了溶血素和磷脂酶之间协同作用的分子机制。我们提出了一个模型，该模型涉及蛋白质之间的相互作用，这种相互作用增加了溶细胞素对膜的亲和力以及直接对裂解的酶促增强作用。
