Lindström M, Jönsson E, Larsson K, Lundbäck B
Respiratory Unit, Department of Occupational Medicine, National Institute for Working Life, Stockholm, Sweden.
Int J Tuberc Lung Dis. 2002 Jan;6(1):76-84.
To assess underdiagnosis of chronic obstructive pulmonary disease.
Two cross-sectional studies of respiratory symptoms and diseases in two population samples of the same age living in the same areas in northern Sweden were performed 6 years apart. In 1986, 5698 (86%) out of 6610 subjects aged 35-36, 50-51 and 65-66 years responded to a postal questionnaire. In 1992 an identical study was performed, and 5617 subjects (87%) out of 6434 responded. Lung function measurements were performed in stratified samples.
Of the subjects diagnosed with chronic bronchitis only 25% in 1986 and 23% in 1992 had been diagnosed prior to the study as having chronic bronchitis, emphysema or chronic obstructive pulmonary disease (COPD). Chronic airflow limitation (CAL), used as a surrogate variable for COPD and defined as FEV1/VC <70% and FEV1 <80% of predicted value, was found in 171 subjects in 1986-1987 (12% of the examined subjects), and 166 subjects in 1993-1994 (11%). In 1986-1987, 26% of the subjects with CAL had been diagnosed as having chronic bronchitis or emphysema prior to the survey, while a diagnosis of either asthma, chronic bronchitis or emphysema, or use of asthma medicines, was found in 58%. The corresponding figures in 1993-1994 were 31% and 63%, respectively. The great majority of the subjects with CAL had recurrent wheeze, dyspnoea and chronic productive cough.
Approximately 60% of the subjects with chronic airflow limitation had been diagnosed prior to the survey as having asthma, chronic bronchitis or emphysema, or were using asthma medicines. The results were similar in 1986-1987 and 1993-1994.
评估慢性阻塞性肺疾病的诊断不足情况。
对居住在瑞典北部同一地区的两个同龄人群样本进行了两项关于呼吸道症状和疾病的横断面研究,两项研究相隔6年。1986年,年龄在35 - 36岁、50 - 51岁和65 - 66岁的6610名受试者中有5698名(86%)回复了邮寄问卷。1992年进行了一项相同的研究,6434名受试者中有5617名(87%)回复。在分层样本中进行了肺功能测量。
在被诊断为慢性支气管炎的受试者中,1986年只有25%、1992年只有23%在研究前被诊断患有慢性支气管炎、肺气肿或慢性阻塞性肺疾病(COPD)。慢性气流受限(CAL)作为COPD的替代变量,定义为FEV1/VC <70%且FEV1 <预测值的80%,在1986 - 1987年的171名受试者中被发现(占检查受试者的12%),在1993 - 1994年的166名受试者中被发现(占11%)。在1986 - 1987年,26%的CAL受试者在调查前被诊断患有慢性支气管炎或肺气肿,而58%的受试者被诊断患有哮喘、慢性支气管炎或肺气肿,或使用过哮喘药物。1993 - 1994年的相应数字分别为31%和63%。绝大多数CAL受试者有反复喘息、呼吸困难和慢性咳痰。
大约60%的慢性气流受限受试者在调查前被诊断患有哮喘、慢性支气管炎或肺气肿,或正在使用哮喘药物。1986 - 1987年和1993 - 1994年的结果相似。