Pinto Pereira L M, Bartholomew L-A, Brooks H, Lowe D, Rocke K, Rolle S, Smith J, Thekwini O, Seemungal T A R, Bekele I
Faculty of Medicine, University of the West Indies, St Augustine, Trinidad and Tobago.
Int J Tuberc Lung Dis. 2007 Sep;11(9):1026-32.
Underdiagnosis of chronic obstructive pulmonary disease (COPD) in asthmatics attending specialty care in Trinidad, West Indies.
To determine the prevalence of COPD in diagnosed asthmatics receiving specialty respiratory care.
In a cross-sectional study, 258 asthmatics were screened for lung function measures to examine forced expiratory volume after 1 second (FEV1), forced vital capacity (FVC) and post-bronchodilator FEV1/FVC (COPD was defined as FEV1/FVC < 70%).
Of 165 patients evaluated (response rate 64.0%), 53 (32.1%, 95%CI 25.0-39.2) had a study diagnosis of COPD and a mean FEV1/FVC of 60.12 +/- 1.2. Proportionally, more males had COPD (50.9%) than asthma (24.1%, P < 0.001). Patients with COPD were 10 years older than asthmatics (P < 0.001). Persons with asthma who smoked were more likely to have COPD (56.0%) (OR 3.26, 95%CI 1.36-7.80, P = 0.006). In both sexes, FEV1/FVC was lower among older people (P < 0.001), with a greater effect (OR 2.75, 95%CI 1.00-7.56, P < 0.01) seen among men in this cross-sectional study.
One third of diagnosed asthmatics in specialty care also have COPD. Lung function was lower among older persons. Early spirometric evaluation of elderly asthmatics who smoke can determine the presence of COPD and facilitate appropriate management.
在西印度群岛特立尼达接受专科护理的哮喘患者中,慢性阻塞性肺疾病(COPD)的诊断不足。
确定接受专科呼吸护理的已确诊哮喘患者中COPD的患病率。
在一项横断面研究中,对258名哮喘患者进行肺功能测量筛查,以检查1秒用力呼气量(FEV1)、用力肺活量(FVC)和支气管扩张剂后FEV1/FVC(COPD定义为FEV1/FVC<70%)。
在165名接受评估的患者中(应答率64.0%),53名(32.1%,95%CI 25.0 - 39.2)经研究诊断为COPD,平均FEV1/FVC为60.12±1.2。按比例计算,患有COPD的男性(50.9%)多于患有哮喘的男性(24.1%,P<0.001)。COPD患者比哮喘患者大10岁(P<0.001)。吸烟的哮喘患者更有可能患有COPD(56.0%)(OR 3.26,95%CI 1.36 - 7.80,P = 0.006)。在男女两性中,老年人的FEV1/FVC较低(P<0.001),在这项横断面研究中,男性的影响更大(OR 2.75,95%CI 1.00 - 7.56,P<0.01)。
在专科护理中,三分之一已确诊的哮喘患者也患有COPD。老年人的肺功能较低。对吸烟的老年哮喘患者进行早期肺量计评估可以确定是否存在COPD,并有助于进行适当的管理。