Henikoff Steven
Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.
Trends Genet. 2002 Apr;18(4):165-7. doi: 10.1016/s0168-9525(01)02622-1.
The inability of current technology to determine contiguous sequence for highly repetitive regions means that centromeres fall within multi-megabase gaps, analogous to black holes from which no information escapes. However, high-resolution mapping of a human X-centromere border reveals a remarkable structure, including a gradient of alpha-satellite divergence up to the edge of the youngest and most homogeneous repeats.
当前技术无法确定高度重复区域的连续序列,这意味着着丝粒位于数百万碱基对的间隙内,类似于没有信息能够逃脱的黑洞。然而,对人类X染色体着丝粒边界的高分辨率图谱显示出一种显著的结构,包括α-卫星序列差异梯度,一直延伸到最年轻、最均匀重复序列的边缘。