Lue Hongqi, Kleemann Robert, Calandra Thierry, Roger Thierry, Bernhagen Jürgen
Laboratory of Biochemistry, Institute for Interfacial Engineering, University of Stuttgart, 70569 Stuttgart, Germany.
Microbes Infect. 2002 Apr;4(4):449-60. doi: 10.1016/s1286-4579(02)01560-5.
Macrophage migration inhibitory factor (MIF) is a unique cytokine and critical mediator of host defenses with a role in septic shock and chronic inflammatory and autoimmune diseases. Its mechanism of action is incompletely understood. Here, we attempt to correlate current knowledge on the molecular pathways of MIF activity with its functions in immunity and disease.
巨噬细胞移动抑制因子（MIF）是一种独特的细胞因子，也是宿主防御的关键介质，在脓毒症休克以及慢性炎症和自身免疫性疾病中发挥作用。其作用机制尚未完全明确。在此，我们试图将目前关于MIF活性分子途径的知识与其在免疫和疾病中的功能联系起来。
