Fundaro A, Cassone M C
Farmaco Sci. 1975 Nov;30(11):891-9.
A study has been made of the acute toxicity, action on the guinea pig ileum, on the ventricle edge, on frog spinal reflex, and on the respiratory and cardiac activity and pulse of the following compounds: 3-methyl-4-furazancarbohydrazide (I); 3-methyl-4-furoxancarbohydrazide (II); 4-methyl-3-furoxancarbohydrazide (III). The compounds had no action on guinea pig ileum or ventricle edge. Compound (I) showed depressant activity on frog spinal reflex whereas compound (II) showed excitation and compound (III) had no direct spinal action. The compounds tested affected respiration and ECG only at the highest doses used. The pulse rate was raised by substance (I) in all cases whereas substances (II) and (III) raised pulse rate only at low doses.
对以下化合物进行了急性毒性研究，以及对豚鼠回肠、心室边缘、青蛙脊髓反射、呼吸和心脏活动及脉搏的作用研究：3-甲基-4-呋喃甲酰肼（I）；3-甲基-4-呋咱甲酰肼（II）；4-甲基-3-呋咱甲酰肼（III）。这些化合物对豚鼠回肠或心室边缘无作用。化合物（I）对青蛙脊髓反射表现出抑制活性，而化合物（II）表现出兴奋作用，化合物（III）无直接脊髓作用。所测试的化合物仅在使用的最高剂量下影响呼吸和心电图。物质（I）在所有情况下均使脉搏率升高，而物质（II）和（III）仅在低剂量时使脉搏率升高。
