[Synthesis and preliminary pharmacological characteristics of various derivatives of 1,2,5-oxadiazole (furazan)].

The synthesis, the chemical properties, the acute toxicity, the action of frog flexor reflex of 4-methylfurazan-3-N-methylcarboxamide (II), 4-methylfurazan-3-N-isopropylcarboxamide (III), 3-methyl-4-morpholinocarbonylfurazan (IV), 3-methyl-4-pyrrolidinocarbonylfurazan (V), 3-amino-4-methylfurazan (VI), 3-acetylamino-4-methylfurazan (VII), are reported. LD50 decrease in the following order: (VI), (II), (IV), (III), (VII), (V). All compounds, except (VII), depressed frog flexor reflexes.