The search for new drugs in the group of xanthine derivatives. XXXIX - Reaction of 1,2-epoxycyclohexane with theophylline and 8-halotheophyllines.

Reaction of 1,2-epoxycyclohexane with theophylline and 8-halotheophyllines in n-butanol n-propanol DMF medium brought up a good yield of the corresponding trans-diequatorial-DL-7-(2'-hydroxycyclohexyl-1')-derivatives (I - III). The products (VII - IX), (XII), (XIII) were formed by nucleophilic displacement of the halogen of (II) or (III) by alkoxides or cyclamines. Acid hydrolysis of the alkoxy derivatives (VII -IX) gave the same compound: 1,3-dimethyl-trans-diequatorial-DL-7-(2'-hydroxycyclohexyl-1')-uric acid (X). The structures of these products were confirmed by U.V., I.R. and N.M.R. spectroscopy.