Schwartz C C, Vlahcevic Z R, Halloran L G, Gregory D H, Meek J B, Swell L
Gastroenterology. 1975 Dec;69(6):1379-82.
A bile fistula patient was administered intravenously a constant infusion of [3H]mevalonic acid for 4 hrs, and then after 2 weeks he was given a pulse of [3H]mevalonic acid. Bile and blood were collected at frequent intervals. The specific activity-time course curves did not show a precursor-product relationship between biliary cholesterol, plasma free cholesterol and bile acids. Both the constant infusion and pulse labeling data indicated that the bile acid precursor had a more rapid rate of turnover than plasma or biliary cholesterol; the biliary cholesterol precursor turned over more rapidly than plasma cholesterol. The data suggest the presence of multiple hepatic cholesterol precursor compartments. Bile acids may be derived predominantly from newly synthesized cholesterol in man.
给一名胆瘘患者静脉持续输注[3H]甲羟戊酸4小时，然后在2周后给予一次[3H]甲羟戊酸脉冲注射。每隔一段时间收集胆汁和血液。比活度-时间进程曲线未显示胆汁胆固醇、血浆游离胆固醇和胆汁酸之间的前体-产物关系。持续输注和脉冲标记数据均表明，胆汁酸前体的周转速度比血浆或胆汁胆固醇更快；胆汁胆固醇前体的周转速度比血浆胆固醇更快。这些数据表明存在多个肝脏胆固醇前体区室。在人类中，胆汁酸可能主要来源于新合成的胆固醇。
