欧洲药典中使用1,3 - 二溴 - 5,5 - 二甲基乙内酰脲（DBH）替代元素溴进行药物鉴别的显色反应。出于环境和经济考量采用DBH的药典分析方法，第10部分。
Colour reactions of PH. EUR. for identification of drugs using 1,3-dibromo-5,5-dimethylhydantoin (DBH) instead of elemental bromine. Analytical methods of pharmacopoeias with DBH in respect to environmental and economical concern, Part 10.
作者信息
Hilp M
机构信息
Institut für Pharmazeutische Chemie der Philipps-Universität, Marburg, Germany.
出版信息
Pharmazie. 2002 Mar;57(3):172-5.
PH. EUR. 2002 and supplements identify aloes (Rosenthaler reaction), amiloride hydrochloride, chlorhexidine, dienestrol, quinidine sulphate, quinine hydrochloride and quinine sulphate (Thalleioquine reaction) and trifluoperazine hydrochloride using elemental bromine. This colour reaction can be performed better with 1,3-dibromo-5,5-dimethylhydantoin (DBH). Some prescriptions of PH. EUR. have been improved in respect to environmental and economical concern. The identification of amiloride hydrochloride with bromine water according to PH. EUR. 2002 or with DBH shows no UV fluorescence as reported in the pharmacopoeia.
欧洲药典2002版及增补本使用元素溴鉴别芦荟（罗森塔尔反应）、盐酸阿米洛利、氯己定、己烯雌酚、硫酸奎尼丁、盐酸奎宁和硫酸奎宁（硫代喹啉反应）以及盐酸三氟拉嗪。使用1,3 - 二溴 - 5,5 - 二甲基乙内酰脲（DBH）能使该显色反应效果更佳。欧洲药典的一些处方在环境和经济方面已有所改进。按照欧洲药典2002版用溴水或用DBH鉴别盐酸阿米洛利时，未呈现药典中所报道的紫外荧光。
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