喷漆工外周血淋巴细胞姐妹染色单体交换的研究。

Studies on sister chromatid exchanges in peripheral lymphocytes of spray painters.

作者信息

Gajalakshmi Palanivel, Mallick Protima, Venkatesan Perumal, Santhiya Sathyaveedu Thiagarjan, Ramesh Arabandi

机构信息

Department of Genetics, Dr. ALMPGIBMS, University of Madras, Taramani Chennai, India.

出版信息

J Environ Pathol Toxicol Oncol. 2002;21(1):63-5.

PMID:11934014

Abstract

In a comparative study of sister chromatid exchanges (SCEs) in cultured lymphocytes, we evaluated the genotoxic risk in 104 male spray painters employed in repair workshops in Chennai City, India, and 50 matched healthy, unexposed controls. We found a higher frequency of SCEs among painters (3.74 +/- 0.11, mean +/- SE) than among controls (2.15 +/- 0.08), and among smoking painters (4.03 +/- 0.21) than among nonsmoking painters (3.55 +/- 0.13), with no significant difference in controls (smokers: 2.1 +/- 0.2; nonsmokers: 2.2 +/- 0.1). Alcoholism did not contribute to an increased SCE frequency. Stepwise multiple linear regression analysis on painters showed that duration of service, smoking, and alcoholism significantly affected SCE scores and explained the 14% variation observed.

摘要

在一项对培养淋巴细胞中姐妹染色单体交换（SCEs）的比较研究中，我们评估了印度钦奈市维修车间工作的104名男性喷漆工以及50名匹配的健康未暴露对照者的遗传毒性风险。我们发现喷漆工中SCEs的频率（3.74±0.11，均值±标准误）高于对照组（2.15±0.08），吸烟的喷漆工（4.03±0.21）高于不吸烟的喷漆工（3.55±0.13），而对照组中吸烟者（2.1±0.2）与不吸烟者（2.2±0.1）之间无显著差异。酗酒并未导致SCE频率增加。对喷漆工进行的逐步多元线性回归分析表明，工作年限、吸烟和酗酒显著影响SCE评分，并解释了观察到的14%的变异。