Muramori F, Kobayashi K, Nakamura I
Department of Neuropsychiatry, Kanazawa University School of Medicine, Japan.
Psychiatry Clin Neurosci. 1998 Dec;52(6):593-9. doi: 10.1111/j.1440-1819.1998.tb02706.x.
The present quantitative study was performed in order to discriminate pathological substrates for dementia from Alzheimer changes in normal controls (NC) and non-Alzheimer neuropsychiatric diseases (NAND). Regional densities of senile plaques (SP), neurofibrillary tangles (NFT) and astrocytes in the cornu ammonis (CA), subiculum and entorhinal cortex were measured and differences in these densities among Alzheimer's disease (AD), NAND and NC were statistically compared. Densities of NFT in the CA and subiculum were significantly higher in AD than in NAND, and densities of SP in all regions were significantly higher in AD than in NAND. Similarly, NFT density in the subiculum and SP density in all regions were higher in AD than in NC. Regional densities of astrocytes in most regions were closely correlated with those of Alzheimer changes. In conclusion, the attribution of the Alzheimer changes, particularly of NFT, to dementia is neglected when they are confined to the entorhinal cortex. However, the attribution of the Alzheimer changes to dementia should be appreciated when they spread from the entorhinal cortex to the subiculum and/or CA.
本定量研究旨在区分正常对照（NC）和非阿尔茨海默神经精神疾病（NAND）中痴呆的病理底物与阿尔茨海默病变。测量了海马角（CA）、海马下脚和内嗅皮质中老年斑（SP）、神经原纤维缠结（NFT）和星形胶质细胞的区域密度，并对阿尔茨海默病（AD）、NAND和NC之间这些密度的差异进行了统计学比较。AD患者CA和海马下脚的NFT密度显著高于NAND患者，AD患者所有区域的SP密度显著高于NAND患者。同样，AD患者海马下脚的NFT密度和所有区域的SP密度高于NC患者。大多数区域的星形胶质细胞区域密度与阿尔茨海默病变的密度密切相关。总之，当阿尔茨海默病变局限于内嗅皮质时，其对痴呆的归因，尤其是NFT的归因被忽视。然而，当阿尔茨海默病变从内嗅皮质扩散到海马下脚和/或CA时，应认识到其对痴呆的归因。
