2,5,4'-三氯联苯在大鼠体内的代谢情况
Fate of 2,5,4'-trichlorobiphenyl in rats.
作者信息
Lay J P, Kamal M, Klein W, Korte F
出版信息
Xenobiotica. 1979 Dec;9(12):713-21. doi: 10.3109/00498257909042339.
PMID:119356
Abstract
- Following the administration of daily oral doses (1 mg/kg) of 2,5,4'-trichloro-[14C]biphenyl to rats for 14 days, the compound was rapidly excreted, only small amounts (3--4%) being stored in the organs. 2. The majority of the biphenyl was metabolized (greater than 85%) and the major metabolites excreted were identified as hydroxy-, dechloro- and conjugated derivatives.
摘要
- 给大鼠每日口服剂量为1毫克/千克的2,5,4'-三氯-[14C]联苯，持续14天，该化合物迅速排出，仅有少量（3 - 4%）储存在器官中。2. 大部分联苯被代谢（超过85%），排出的主要代谢产物被鉴定为羟基、脱氯和共轭衍生物。
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