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2,4',5-三氯联苯通过巯基尿酸途径的代谢

Metabolism of 2,4',5-trichlorobiphenyl by the mercapturic acid pathway.

作者信息

Bakke J E, Bergman A L, Larsen G L

出版信息

Science. 1982 Aug 13;217(4560):645-7. doi: 10.1126/science.6806905.

Abstract

Carbon-14-labeled 2,4',5-trichlorobiphenyl was found to be metabolized by the mercapturic acid pathway to metabolites that are excreted in bile. About 57 percent of the carbon-14 was excreted in the bile; 30 to 35 percent was present as mercapturic acid pathway metabolites. Mercapturic acid was also isolated from the urine (0.3 percent of the dose).

摘要

碳 - 14标记的2,4',5 - 三氯联苯经巯基尿酸途径代谢为经胆汁排泄的代谢物。约57%的碳 - 14经胆汁排泄;30%至35%以巯基尿酸途径代谢物形式存在。尿液中也分离出了巯基尿酸(占剂量的0.3%)。

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