Maeda Nagamasa, Izumiya Chiaki, Oguri Hiroyoshi, Kusume Tomoaki, Yamamoto Yorito, Fukaya Takao
Department of Obstetrics and Gynecology, Kochi Medical School, Kohasu, Oko, Nankoku, Kochi, Japan.
Fertil Steril. 2002 Apr;77(4):679-83. doi: 10.1016/s0015-0282(01)03249-6.
To investigate host immunologic response to endometriosis in terms of intercellular adhesion molecule (ICAM)-1 expression by macrophages and killer cell inhibitory receptor (KIR) expression by natural killer (NK) cells.
Case-control study of immunologic markers.
University hospital.
PATIENT(S): Twenty-eight Japanese women with endometriosis. Control subjects were 26 women without endometriosis. Diagnoses were made at laparoscopy.
INTERVENTION(S): Venipuncture and laparoscopic peritoneal fluid collection.
MAIN OUTCOME MEASURE(S): ICAM-1 expression by macrophages and KIR expression by NK cells, measured by flow cytometry.
RESULT(S): In women with endometriosis, expression of ICAM-1 by peritoneal macrophages was significantly lower and expression of KIR by NK cells in peritoneal fluid and peripheral blood was significantly higher than in control subjects.
CONCLUSION(S): Properties of macrophages and NK cells in women with endometriosis promote immunotolerance to implanted tissue in the peritoneal environment. Increased KIR(+)NK cells in peripheral blood may represent a risk factor for endometriosis.
从巨噬细胞细胞间黏附分子（ICAM）-1表达及自然杀伤（NK）细胞杀伤细胞抑制受体（KIR）表达方面，研究宿主对子宫内膜异位症的免疫反应。
免疫标志物的病例对照研究。
大学医院。
28名患有子宫内膜异位症的日本女性。对照为26名无子宫内膜异位症的女性。诊断通过腹腔镜检查做出。
静脉穿刺及腹腔镜下收集腹腔液。
通过流式细胞术测定巨噬细胞ICAM-1表达及NK细胞KIR表达。
患有子宫内膜异位症的女性中，腹腔巨噬细胞ICAM-1表达显著降低，腹腔液及外周血中NK细胞KIR表达显著高于对照组。
子宫内膜异位症女性巨噬细胞和NK细胞特性促进对腹腔环境中植入组织的免疫耐受。外周血中KIR(+)NK细胞增加可能是子宫内膜异位症的一个危险因素。
