高效抗逆转录病毒疗法对HIV感染患者不明原因发热的影响。
Impact of highly active antiretroviral therapy on fever of unknown origin in HIV-infected patients.
作者信息
Lozano F, Torre-Cisneros J, Santos J, León E, Domínguez A, Montesdeoca M, Selma D, Terrón A
机构信息
Infectious Diseases Section, Hospital Universitario de Valme, Seville, Spain.
出版信息
Eur J Clin Microbiol Infect Dis. 2002 Feb;21(2):137-9. doi: 10.1007/s10096-001-0676-y.
In order to assess the impact of highly active antiretroviral therapy (HAART) on the frequency and etiology of fever of unknown origin in HIV-infected patients, a retrospective study was performed on cases of fever of unknown origin observed from January 1997 to December 1999 in seven hospitals in five cities in Andalusia, Spain. During the period specified, a total of 4,858 HIV-infected patients receiving HAART and 2,787 HIV-infected individuals not receiving HAART were studied. The frequency of fever of unknown origin was 0.6% in patients receiving HAART and 3% in non-HAART patients (P=0.001). Human immunodeficiency virus infection was the only cause of fever found more frequently in the non-HAART patient group (P=0.07). The study findings suggest that the use of HAART has reduced the frequency of fever of unknown origin in HIV-infected patients, but the etiology of the condition remains mostly unchanged.
为评估高效抗逆转录病毒疗法（HAART）对HIV感染患者不明原因发热的频率及病因的影响，对1997年1月至1999年12月期间在西班牙安达卢西亚五个城市的七家医院观察到的不明原因发热病例进行了一项回顾性研究。在指定期间，共研究了4858例接受HAART的HIV感染患者和2787例未接受HAART的HIV感染个体。接受HAART的患者中不明原因发热的频率为0.6%，未接受HAART的患者中为3%（P=0.001）。人类免疫缺陷病毒感染是在未接受HAART的患者组中更频繁发现的唯一发热原因（P=0.07）。研究结果表明，使用HAART降低了HIV感染患者不明原因发热的频率，但该病的病因大多保持不变。
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