Rosin M, Splieth Ch, Hessler M, Gärtner Ch, Kordass B, Kocher T
Department of Operative Dentistry, Periodontology, and Pediatric Dentistry, University of Greifswald, Germany.
J Clin Periodontol. 2002 Mar;29(3):240-6. doi: 10.1034/j.1600-051x.2002.290310.x.
The aim of the study was to investigate the suitability of measuring volume differences in the gingival tissue for monitoring changes in the inflammatory status of the gingiva.
Data for this investigation were obtained from a mouthrinse evaluation which was performed as a 4-week, double-blind, placebo-controlled, cross-over study in which localised experimental gingivitis was induced. 24 volunteers were enrolled in the study. Only the data from the placebo period of each subject were used in the current investigation. During the plaque accumulation periods, plaque guards were worn during routine performance of oral hygiene measures to prevent any plaque removal from the experimental area (1st and 2nd premolars and molars in one upper quadrant). Clinical examinations with assessment of plaque and gingivitis were performed on days 0, 4, 7, 14, 21, 28 and 42. Volume differences in the gingival papillae were determined between day 0 and days 21, 28, and 42, and between days 28 and 42 by taking measurements from replicas of the respective clinical situations using a 3-D laser scanner and reference-free automated 3-D superimposition software. Data were analysed with the Wilcoxon signed ranks test.
Plaque accumulation in the experimental area resulted in a highly significant increase (p<0.001) of inflammation of the gingival papillae. The mean (standard deviation) papillary GI at baseline was 0.23 (0.34) as compared to 1.22 (0.27) and 1.2 (0.31) on days 21 and 28, respectively. The mean increase in volume of all papillae as compared to baseline was 25,478 micrometer3 after 21 days and 24,210 micrometer3 after 28 days. After resuming a normal oral hygiene regimen, mean volume of the papillae decreased between days 28 and 42 by 19,250 micrometer3.
With this novel method, gingival papillary edema can be quantified in vivo from replicas of the clinical situation.
本研究旨在探讨测量牙龈组织体积差异以监测牙龈炎症状态变化的适用性。
本调查的数据来自一项为期4周的含漱液评估，该评估为双盲、安慰剂对照、交叉研究，其中诱发了局限性实验性牙龈炎。24名志愿者参与了该研究。在本次调查中仅使用了每个受试者安慰剂期的数据。在菌斑积聚期，在日常口腔卫生措施实施过程中佩戴菌斑防护装置，以防止从实验区域（一个上象限的第一和第二前磨牙及磨牙）去除任何菌斑。在第0、4、7、14、21、28和42天进行了菌斑和牙龈炎评估的临床检查。通过使用三维激光扫描仪和无参考自动三维叠加软件从各自临床情况的复制品中进行测量，确定第0天与第21、28和42天之间以及第28天与第42天之间牙龈乳头的体积差异。数据采用Wilcoxon符号秩检验进行分析。
实验区域的菌斑积聚导致牙龈乳头炎症显著增加（p<0.001）。基线时平均（标准差）乳头牙龈指数为0.23（0.34），而在第21天和第28天分别为1.22（0.27）和1.2（0.31）。与基线相比，所有乳头的平均体积在21天后增加了25478立方微米，在28天后增加了24210立方微米。在恢复正常口腔卫生方案后，乳头的平均体积在第28天至第42天之间减少了19250立方微米。
通过这种新方法，可以从临床情况的复制品中对体内牙龈乳头水肿进行量化。
