Pairon Jean-Claude, Matrat Mireille, Brochard Patrick
Service de pneumologie et de pathologie professionnelle, CHI, 40, avenue de Verdun, 94010 Créteil Cedex.
Bull Cancer. 2002 Mar;89(3):283-92.
Despite the knowledge of the link between many sites of cancer occurence and previous occupational exposure, occupational cancers are generally underestimated. These cancers can be prevented through specific plans. In France, the number of cases requesting and receiving compensation for occupational cancer is increasing. The frequency of occupational exposure to carcinogens was recently evaluated. Legislation was reinforced in order to obtain a better control of exposure to carcinogens in the workplace. Lung cancer is the most frequent of occupational cancers. Epidemiological studies contribute to a better knowledge of etiologies and occupations responsible for the outcome of these cancers and allow quantification of the risk of cancer linked to different situations of exposure. Beside classical epidemiological studies, molecular epidemiology aims at identifying molecular targets of occupational agents. This approach may allow a better knowledge of the part played by occupational agents in these multifactorial diseases.
尽管人们已经了解到许多癌症发生部位与既往职业暴露之间的联系，但职业性癌症总体上仍被低估。这些癌症可以通过特定计划加以预防。在法国，申请并获得职业性癌症赔偿的病例数量正在增加。最近对职业接触致癌物的频率进行了评估。为了更好地控制工作场所中致癌物的接触，相关立法得到了加强。肺癌是最常见的职业性癌症。流行病学研究有助于更深入地了解这些癌症发生的病因和相关职业，并能够量化与不同接触情况相关的癌症风险。除了经典的流行病学研究外，分子流行病学旨在识别职业性致癌因素的分子靶点。这种方法可能有助于更好地了解职业性致癌因素在这些多因素疾病中所起的作用。
