Crawford F C, Vanderploeg R D, Freeman M J, Singh S, Waisman M, Michaels L, Abdullah L, Warden D, Lipsky R, Salazar A, Mullan M J
Roskamp Institute, University of South Florida, Tampa 33613, USA.
Neurology. 2002 Apr 9;58(7):1115-8. doi: 10.1212/wnl.58.7.1115.
APOE has been demonstrated to influence traumatic brain injury (TBI) outcome. The relationship between APOE genotype and memory following TBI was examined in 110 participants in the Defense and Veterans' Head Injury Program. Memory performance was worse in those who had an APOE epsilon 4 allele (n = 30) than those who did not (n = 80), whereas genotype groups did not differ on demographic or injury variables or on measures of executive functioning. These data support a specific role for the APOE protein in memory outcome following TBI, and suggest an APOE isoform-specific effect on neuronal repair processes.
已证实载脂蛋白E（APOE）会影响创伤性脑损伤（TBI）的预后。在国防与退伍军人头部损伤项目的110名参与者中，研究了APOE基因型与TBI后记忆之间的关系。携带APOE ε4等位基因的人（n = 30）的记忆表现比未携带该等位基因的人（n = 80）更差，而不同基因型组在人口统计学或损伤变量以及执行功能测量方面并无差异。这些数据支持了APOE蛋白在TBI后记忆预后中所起的特定作用，并表明APOE异构体对神经元修复过程具有特异性影响。
