Sajatovic M., Meltzer H. Y.
Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Convuls Ther. 1993;9(3):167-175.
The effect of electroconvulsive therapy (ECT) plus loxapine in nine patients with treatment-refractory schizophrenia or schizoaffective disorder was studied in an open trial. Five of the nine patients (55.6%) improved significantly (>/=20%) in the Brief Psychiatric Rating Scale total scores by the end of the course of ECT. Improvement was greater in positive than in negative symptoms. A sixth patient improved 3-6 weeks after the completion of the acute course of ECT. Five patients who responded to ECT received maintenance ambulatory ECT; two patients remained improved for at least 6-9 months, whereas the other three relapsed within 4 months. Further study of the indications for and the effectiveness of ECT plus neuroleptic drugs in treatment-resistant schizophrenia is indicated.
在一项开放性试验中，研究了电休克疗法（ECT）联合洛沙平对9例难治性精神分裂症或分裂情感性障碍患者的疗效。9例患者中有5例（55.6%）在ECT疗程结束时简明精神病评定量表总分显著改善（≥20%）。阳性症状的改善大于阴性症状。第6例患者在ECT急性疗程结束后3 - 6周出现改善。5例对ECT有反应的患者接受了维持性非住院ECT治疗；2例患者至少6 - 9个月病情持续改善，而另外3例在4个月内复发。表明需要进一步研究ECT联合抗精神病药物治疗难治性精神分裂症的适应证和有效性。
