Frankenburg Frances R., Suppes Trisha, McLean Paul E.
Consolidated Department of Psychiatry, Harvard Medical School, Belmont, Massachusetts, USA.
Convuls Ther. 1993;9(3):176-180.
We reviewed consecutive patients (n = 12) at McLean Hospital from 1990 through 1991 treated with the combination of the atypical antipsychotic agent clozapine and electroconvulsive therapy (ECT). There were no adverse effects. Three patients had a marked clinical improvement, one a moderate response, four a minimal response, two minimal to no response, and two no response. Using daily doses of up to 550 mg clozapine, this combination appears to be safe, and may be useful in some patients with treatment-refractory psychosis.
我们回顾了1990年至1991年在麦克莱恩医院连续接受非典型抗精神病药物氯氮平与电休克治疗（ECT）联合治疗的患者（n = 12）。未出现不良反应。3例患者临床症状显著改善，1例中度缓解，4例轻度缓解，2例缓解不明显或无缓解，2例无缓解。使用每日剂量高达550毫克的氯氮平，这种联合治疗似乎是安全的，可能对一些难治性精神病患者有用。
