Kho K H, Blansjaar B A, de Vries S, Babuskova D, Zwinderman A H, Linszen D H
GGZ Delfland, St Jorisweg 2, 2612 GA Delft, The Netherlands.
Eur Arch Psychiatry Clin Neurosci. 2004 Dec;254(6):372-9. doi: 10.1007/s00406-004-0517-y. Epub 2004 Nov 12.
This open label study describes the efficacy of electroconvulsive therapy (ECT) as adjunctive treatment in clozapine nonresponders suffering from schizophrenia.
The results of clozapine and ECT treatment in 11 clozapine nonresponders suffering from schizophrenia are reported in terms of remission and relapse.
Eight patients had a remission with this combination treatment. After remission of symptoms five patients had a relapse. Three of the five patients who relapsed had a second successful ECT course and remained well with maintenance ECT and clozapine. No evidence for adverse effects was found.
Adjunctive ECT can be efficacious in clozapine nonresponders suffering from schizophrenia.
本开放性标签研究描述了电休克治疗（ECT）作为辅助治疗对氯氮平治疗无效的精神分裂症患者的疗效。
报告了11例氯氮平治疗无效的精神分裂症患者接受氯氮平和ECT治疗后的缓解及复发情况。
8例患者通过联合治疗获得缓解。症状缓解后，5例患者复发。复发的5例患者中有3例接受第二次ECT治疗成功，通过维持ECT和氯氮平治疗病情稳定。未发现不良反应的证据。
辅助ECT治疗对氯氮平治疗无效的精神分裂症患者可能有效。
