Serio G, Scattone A, Pennella A, Giardina C, Musti M, Valente T, Pollice L
Department of Pathological Anatomy and Genetics, University of Bari, Bari, Italy.
Histopathology. 2002 Apr;40(4):348-52. doi: 10.1046/j.1365-2559.2002.01373.x.
To present two rare cases of malignant mesotheliomas with deciduoid features arising in the pleura, both with long survival.
These two cases of deciduoid mesotheliomas were observed in adult patients (one 73-year-old male and one 23-year-old female). Only the male had a history of occupational asbestos exposure, whereas the woman had a history of familial mesothelioma. A deciduoid morphology was predominant and focal areas with tubular-papillary features were noted. The tumour cells were positive for cytokeratins, HMBE-1, calretinin, EMA and mitochondrion antibodies. The follow-up data did not suggest a particularly poor prognosis; the mean survival observed was 23 months (17 and 39 months, respectively).
This deciduoid mesothelioma histological subtype does not appear to represent an unfavourable prognostic category.
介绍两例罕见的具有蜕膜样特征的恶性间皮瘤，均起源于胸膜，且生存期均较长。
这两例蜕膜样间皮瘤见于成年患者（一名73岁男性和一名23岁女性）。仅男性有职业性石棉接触史，而女性有家族性间皮瘤病史。以蜕膜样形态为主，可见局灶性的管状乳头样特征区域。肿瘤细胞细胞角蛋白、HMBE-1、钙视网膜蛋白、上皮膜抗原和线粒体抗体检测均为阳性。随访数据未提示预后特别差；观察到的平均生存期为23个月（分别为17个月和39个月）。
这种蜕膜样间皮瘤组织学亚型似乎并不代表预后不良的类别。
