Specchia Giorgina, Albano Francesco, Anelli Luisa, Storlazzi Clelia Tiziana, Monaco Michele, Capalbo Silvana, Rocchi Mariano, Liso Vincenzo
Department of Hematology, University of Bari, Policlinico, 70124 Bari, Italy.
Cancer Genet Cytogenet. 2002 Mar;133(2):160-3. doi: 10.1016/s0165-4608(01)00583-0.
Chronic lymphocytic leukemia (CLL) associated with myeloid antigens on the surface of B neoplastic cells is a recently identified immunologic variant confined to patients with CD5 negative B-CLL. We describe the case of a 61-year-old female diagnosed with CD5(-), CD13(+) B-CLL with a tetrasomy 3q revealed by fluorescence in situ hybridization analysis, in addition to trisomy 18. To our knowledge, this is the first reported case of B-CLL with this kind of cytogenetic abnormality.
与B肿瘤细胞表面髓系抗原相关的慢性淋巴细胞白血病（CLL）是一种最近发现的免疫变异型，仅见于CD5阴性的B-CLL患者。我们描述了一例61岁女性患者，诊断为CD5（-）、CD13（+）的B-CLL，荧光原位杂交分析显示除18号染色体三体外，还有3号染色体长臂四体。据我们所知，这是首例报道的具有这种细胞遗传学异常的B-CLL病例。
