Cordeaux Yolande, Hill Stephen J
Institute of Cell Signalling and School of Biomedical Sciences, Queens Medical Centre, Nottingham, UK.
Neurosignals. 2002 Jan-Feb;11(1):45-57. doi: 10.1159/000057321.
There is increasing evidence to suggest that 'cross-talk' occurs between G-protein-coupled receptors and their intracellular second messenger pathways. Cross-talk between different pathways may occur at the level of receptors, G-proteins, effectors or second messengers and may serve to fine-tune cell signalling. There is a growing body of evidence to suggest that cellular compartmentalization may play a crucial role in regulating these cross-talk interactions. Understanding the mechanisms of cross-talk may therefore be the key to the design and application of future therapeutics and the development of drug specificity.
越来越多的证据表明，G蛋白偶联受体与其细胞内第二信使途径之间会发生“串扰”。不同途径之间的串扰可能发生在受体、G蛋白、效应器或第二信使水平，并且可能有助于微调细胞信号传导。越来越多的证据表明，细胞区室化可能在调节这些串扰相互作用中起关键作用。因此，了解串扰机制可能是未来疗法设计与应用以及药物特异性开发的关键。
