Marczewska Jadwiga, Koziorowska Jadwiga H
Department of Vitamins, Drug Institute, Warsaw, Poland.
Int J Vitam Nutr Res. 2002 Mar;72(2):85-9. doi: 10.1024/0300-9831.72.2.85.
SOS chromotest was employed to study the interaction of ascorbic acid with free ions of transient metals in the presence of added catalase, superoxide dismutase or D-mannitol. Catalase diminished the genotoxic activity of the mixture of ascorbic acid with copper ions in E. coli strains PQ37 and PQ 300, but genotoxicity of this mixture was not suppressed by superoxide dismutase and D-mannitol. The results suggest that copper ions diminished the content of peroxide generated by ascorbic acid.
采用SOS比色试验研究了在添加过氧化氢酶、超氧化物歧化酶或D-甘露醇的情况下，抗坏血酸与过渡金属游离离子之间的相互作用。过氧化氢酶降低了抗坏血酸与铜离子混合物在大肠杆菌菌株PQ37和PQ300中的遗传毒性活性，但超氧化物歧化酶和D-甘露醇并未抑制该混合物的遗传毒性。结果表明，铜离子降低了抗坏血酸产生的过氧化物含量。
