Gajewska J, Szczypka M, Tudek B, Szymczyk T
Department of Biochemistry, Institute of Biopharmacy, Medical School, Warsaw, Poland.
Mutat Res. 1990 Oct;232(2):191-7. doi: 10.1016/0027-5107(90)90124-m.
The genotoxic properties of nitrofurazone and furazolidone were studied using the Ames test and SOS-chromotest. Both compounds were found to act as strong mutagens on the TA97 and TA102 strains of S. typhimurium and to induce the SOS-repair system in the PQ37 strain of E. coli. A good concordance was found between the mutagenic activity and the ability to induce the SOS system. Ascorbic acid and sodium selenite only very slightly lowered the genotoxic effect of the 2 nitrofurans studied both in the Ames test and in the SOS-chromotest.
