Islam S, Bures J, Buresová O
J Comp Physiol Psychol. 1975 Jul;89(5):427-32. doi: 10.1037/h0077048.
Cortical spreading depression (CSD) was employed in rats to study the lateralization of extinction of a jumping avoidance reaction. Under unilateral CSD, 181 nonreinforced trials were needed to extinguish the avoidance reaction acquired in three 100-trial sessions of intact-brain training. During a second extinction session, either with the same or with the contralateral hemisphere depressed, the mean number of trials to the extinction criterion (9/10) was 39 (n = 12) or 186 (n = 15), respectively. Five extinction trials performed with the brain intact 1 hr before extinction with contralateral CSD decreased the number of trials to extinction of 98 (n = 11). Thus, extinction of active avoidance can be lateralized and interhemispherically transferred in the same way as acquisition of this habit.
在大鼠中采用皮质扩散性抑制（CSD）来研究跳跃回避反应消退的侧化情况。在单侧CSD条件下，需要181次非强化试验才能使在完整大脑训练的三个100次试验阶段中获得的回避反应消退。在第二个消退阶段，无论是同一半球还是对侧半球受到抑制，达到消退标准（9/10）的平均试验次数分别为39次（n = 12）或186次（n = 15）。在对侧CSD消退前1小时进行5次大脑完整状态下的消退试验，可将达到消退的试验次数减少至98次（n = 11）。因此，主动回避的消退可以像这种习惯的习得一样进行侧化并在半球间转移。
