Xie Jiang-Tao, Gu Jie-Fu
Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, P. R. China 430071.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2002 Mar;16(2):112-3.
To study the effect of autogenous bone marrow on guided bone regeneration (GBR), and evaluate the repairing ability of GBR in bone defect with autogenous bone marrow.
Ten mm segmental defects were produced in both radii of 18 rabbits. The defect was bridged with a silicon tube. Autogenous bone marrow was injected into the tube on the experimental group at 0, 2, 4 weeks after operation, and peripheral blood into the control group at the same time. The X-ray, gross, histological and biochemical examinations were observed in various times.
The new bone formation of experimental group was prior to that of control group; calcium and alkaline phosphatase of experimental group were higher than those of control group. The experimental group had all been healed at the tenth week, but no one healed in control group.
It can be conclude that autogenous bone marrow can stimulate bone formation and facilitate GBR in bone defect.
研究自体骨髓对引导骨再生（GBR）的作用，并评估GBR在自体骨髓存在情况下对骨缺损的修复能力。
在18只兔子的双侧桡骨制造10毫米节段性骨缺损。用硅管桥接骨缺损。实验组在术后0、2、4周将自体骨髓注入管内，对照组在相同时间注入外周血。在不同时间进行X线、大体、组织学和生化检查。
实验组新骨形成早于对照组；实验组的钙和碱性磷酸酶高于对照组。实验组在第10周全部愈合，而对照组无一愈合。
可以得出结论，自体骨髓可刺激骨形成并促进GBR对骨缺损的修复。
