Paris G, Sponsel W E, Sandoval S S, Elliott W R, Trigo Y, Sanford D K, Harison J M
South Texas Ocular Imaging Center, Ophthalmology Department, University of Texas Health Science Center at San Antonio, USA.
Int Ophthalmol. 2001;23(4-6):355-8. doi: 10.1023/a:1014410932321.
Our goal was to determine whether visual system responses to sildenafil accompany shifts in ocular perfusion. The human choroid, which supports the metabolic function of the outer retina, is an erectile tissue, analogous in many respects to the corpus cavenosum.
Right eyes of 12 normal adults were evaluated before and 2 h after 50 mg oral dose of sildenafil. Pulsatile ocular blood flow (POBF), intraocular pressure (IOP), Heidelberg retinal flowmetry (HRT), 4.26 cpd, 7.5 Hz temporally-modulated contrast sensitivity (CS), full-threshold C-20 frequency doubling technology (FDT) perimetry, and blood pressure (BP) were measured.
POBF (+29.4%; p > 0.016) and CS (+33.6%; p > 0.014%) increased within 110 (+/-7.7) minutes after sildenafil administration. No subject demonstrated decreases in either variable. HRF flow values increase among 7 of the 9 eyes producing stable scans (+8.2%; p > 0.1). FDT values did not change significantly, nor did systemic pulse amplitude or mean IOP.
Since IOP and systemic pulse amplitude both remained stable after sildenafil administration, while POBF values increased to a level nearly one third greater than baseline. It appears sildenafil can induce intrinsic change in the choroidal vasculature, with an apparently positive impact on pericentral contrast sensitivity. This effect may be of clinical utility.
我们的目标是确定视觉系统对西地那非的反应是否伴随着眼部灌注的变化。支持视网膜外层代谢功能的人脉络膜是一种勃起组织，在许多方面类似于海绵体。
对12名正常成年人的右眼在口服50毫克西地那非之前和之后2小时进行评估。测量搏动性眼血流量（POBF）、眼压（IOP）、海德堡视网膜血流仪（HRT）、4.26周/度、7.5赫兹时间调制对比敏感度（CS）、全阈值C-20频率加倍技术（FDT）视野检查和血压（BP）。
服用西地那非后110（±7.7）分钟内，POBF（+29.4%；p>0.016）和CS（+33.6%；p>0.014%）增加。没有受试者在任何一个变量上出现下降。在9只产生稳定扫描的眼中，有7只眼的HRF血流值增加（+8.2%；p>0.1）。FDT值没有显著变化，全身脉搏幅度或平均IOP也没有变化。
由于服用西地那非后眼压和全身脉搏幅度均保持稳定，而POBF值增加到比基线水平高出近三分之一的水平。看来西地那非可以诱导脉络膜血管系统发生内在变化，对中心周围对比敏感度有明显的积极影响。这种作用可能具有临床应用价值。
