Metelitsina Tatyana I, Grunwald Juan E, DuPont Joan C, Ying Gui-shuang
Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, 51 North 39th Street, Philadelphia, PA 19104, USA.
Exp Eye Res. 2005 Aug;81(2):159-64. doi: 10.1016/j.exer.2005.01.017.
To investigate the effects of sildenafil citrate (Viagra) on foveolar choroidal circulation in patients with age related macular degeneration (AMD). Double-blinded, randomized, placebo-controlled, crossover study. Fifteen male AMD patients received a dose of 100 mg of sildenafil or matching placebo on two separate days. Laser Doppler flowmetry was performed to assess relative choroidal blood velocity (ChB(Vel)), volume (ChB(Vol)) and flow (ChB(Flow)) in the study eye prior to administration of the drug at baseline and 30, 90, 180, 300 min after dosing. Best corrected visual acuity (BCVA), contrast sensitivity (CS), mean arterial blood pressure (BPm), heart rate (HR), intraocular pressure (IOP) and ocular perfusion pressure (PP) were determined. In comparison to placebo, sildenafil did not cause any statistically significant changes in mean ChB(Vel) (ANOVA, P=0.12), ChB(Vol) (ANOVA, P=0.24) or ChB(Flow) (ANOVA, P=0.46). There were no statistically significant changes in CS (ANOVA, P=0.59), BCVA (P=0.58), IOP (P=0.81) or HR (P=0.07) throughout the study. Significant decreases in BPm (P=0.006) and PP (P=0.006) were observed at 30 min after sildenafil. Administration of sildenafil citrate didn't cause any statistically significant changes in the foveolar choroidal circulation of AMD patients.
探讨枸橼酸西地那非（万艾可）对年龄相关性黄斑变性（AMD）患者黄斑区脉络膜循环的影响。双盲、随机、安慰剂对照、交叉研究。15例男性AMD患者在两个不同日期分别接受100mg西地那非或匹配的安慰剂。在给药前基线以及给药后30、90、180、300分钟，使用激光多普勒血流仪评估研究眼的脉络膜相对血流速度（ChB(Vel)）、血容量（ChB(Vol)）和血流量（ChB(Flow)）。测定最佳矫正视力（BCVA）、对比敏感度（CS）、平均动脉血压（BPm）、心率（HR）、眼压（IOP）和眼灌注压（PP）。与安慰剂相比，西地那非在平均ChB(Vel)（方差分析，P = 0.12）、ChB(Vol)（方差分析，P = 0.24）或ChB(Flow)（方差分析，P = 0.46）方面未引起任何统计学上的显著变化。在整个研究过程中，CS（方差分析，P = 0.59）、BCVA（P = 0.58）、IOP（P = 0.81）或HR（P = 0.
