Bilfinger T V, Stefano George B
Cardiothoracic Division, Department of Surgery, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, New York 11794, USA.
Curr Pharm Des. 2002;8(7):505-9. doi: 10.2174/1381612023395763.
This review discusses the role of protease inhibition with emphasis on the effects of inflammation and vascular immune phenomena in non-immunocompromised hosts. A vast body of knowledge elucidating the role of protease inhibition and hemostasis has accumulated in recent years. The two subjects are intimately linked, but the focus of this review is limited to the anti-inflammatory effects of protease inhibitors. In light of the particular expertise of the present authors, this review will focus on human studies and often cite work related to open-heart surgery, since in recent years this is the area in which a large effort has been concentrated worldwide.
本综述讨论了蛋白酶抑制的作用，重点关注炎症和血管免疫现象在非免疫受损宿主中的影响。近年来，关于蛋白酶抑制作用和止血作用的大量知识不断积累。这两个主题紧密相连，但本综述的重点仅限于蛋白酶抑制剂的抗炎作用。鉴于本文作者的专业特长，本综述将聚焦于人体研究，并经常引用与心脏直视手术相关的研究，因为近年来这是全球范围内大量研究工作集中的领域。
