Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara, Japan.
Inflamm Res. 2010 Sep;59(9):679-87. doi: 10.1007/s00011-010-0205-5. Epub 2010 May 8.
Protease inhibitors, including the Kunitz, Kazal, serpin and mucus families, play important roles in inhibiting protease activities during homeostasis, inflammation, tissue injury, and cancer progression. Interestingly, in addition to their anti-protease activity, protease inhibitors also often possess other intrinsic properties that contribute to termination of the inflammatory process, including modulation of cytokine expression, signal transduction and tissue remodeling. In this review we have tried to summarize recent findings on the Kunitz family of serine proteinase inhibitors and their implications in health and disease.
A systematic search was performed in the electronic databases PubMed and ScienceDirect up to October 2009. We tried to limit the review to anti-inflammatory actions and actions not related to protease inhibition.
Recent studies have demonstrated that the Kunitz inhibitors are not only protease inhibitors, but can also prevent inflammation and tissue injury and subsequently promote tissue remodeling.
蛋白酶抑制剂，包括 Kunitz、Kazal、丝氨酸蛋白酶抑制剂和黏液家族，在体内平衡、炎症、组织损伤和癌症进展过程中抑制蛋白酶活性方面发挥着重要作用。有趣的是，除了其抗蛋白酶活性外，蛋白酶抑制剂通常还具有其他内在特性，有助于终止炎症过程，包括调节细胞因子表达、信号转导和组织重塑。在这篇综述中，我们试图总结丝氨酸蛋白酶抑制剂 Kunitz 家族的最新发现及其在健康和疾病中的意义。
在电子数据库 PubMed 和 ScienceDirect 中进行了系统搜索，截至 2009 年 10 月。我们试图将综述限制在抗炎作用和与蛋白酶抑制无关的作用上。
最近的研究表明，Kunitz 抑制剂不仅是蛋白酶抑制剂，还可以预防炎症和组织损伤，从而促进组织重塑。
