Juengling Freimut D, Kassubek Jan, Högerle Stefan, Nitzsche Egbert U, Moser Ernst
Division of Nuclear Medicine, Department of Radiology, University Hospital Freiburg, Freiburg, Germany.
J Magn Reson Imaging. 2002 Apr;15(4):456-61. doi: 10.1002/jmri.10086.
To improve analysis of cerebral white matter (WM) in fluoro-deoxy-glucose positron emission tomography (PET) images.
A multimodality analysis technique (segmented MRI and registered Talairach-transformed PET [SMART-PET]) was used for quantitative assessment of WM metabolism. Data processing included Talairach transformation of three-dimensional magnetic resonance imaging (MRI) and subsequent automated segmentation and coregistration to normalized PET images. Color model transformations were used for combined display: the hue saturation value color model was regarded as a three-dimensional data matrix, integrating quantitative voxel data of both modalities. The technique was applied in normal subjects and in patients suffering from different WM diseases. Regional analysis was performed to classify metabolic impairment on a five-point scale.
Using SMART-PET, a considerable gain in image contrast for WM was achieved in all cases. In the normal subjects, WM metabolism was shown to be homogeneously unimpaired. Sum scores of regional analysis revealed metabolic WM changes in all patients. Extent of WM hypometabolism exceeded the extent of the lesions as delineated by MRI signal changes.
The potential of the method for further elucidation of the role of WM diseases in brain dysfunction in patients is discussed.
改进氟脱氧葡萄糖正电子发射断层扫描（PET）图像中脑白质（WM）的分析。
采用多模态分析技术（分段MRI和配准的Talairach变换PET[SMART-PET]）对WM代谢进行定量评估。数据处理包括三维磁共振成像（MRI）的Talairach变换以及随后的自动分割和与标准化PET图像的配准。颜色模型变换用于联合显示：色相饱和度值颜色模型被视为一个三维数据矩阵，整合了两种模态的定量体素数据。该技术应用于正常受试者和患有不同WM疾病的患者。进行区域分析以按五分制对代谢损害进行分类。
使用SMART-PET，在所有病例中WM的图像对比度都有显著提高。在正常受试者中，WM代谢显示均匀未受损。区域分析的总分显示所有患者的WM代谢有变化。WM代谢减退的范围超过了MRI信号变化所描绘的病变范围。
讨论了该方法在进一步阐明WM疾病在患者脑功能障碍中的作用方面的潜力。
