Mathews S, Al Mulla A, Varghese P K, Radim K, Mumtaz S
Department of Anaesthesia and ICU, Mubarak Al-Kabir Hospital, Hawally, Kuwait.
Anaesthesia. 2002 Apr;57(4):394-8. doi: 10.1046/j.1365-2044.2002.2457_3.x.
We studied whether tramadol administered at the time of wound closure can prevent postanaesthetic shivering. One hundred and fifty patients scheduled for general anaesthesia and surgery were randomly allocated and tramadol was administered intravenously at a dose of 2 mg.kg(-1) in the high-dose group, 1 mg.kg- in the low-dose group and 0.9% saline in the control group. In the high-dose group, 2% of patients had postanaesthetic shivering, compared to 4% in the low-dose group and 48% in the control group (p < 0.001 vs. tramadol groups). There was no delay in tracheal extubation after reversal of neuromuscular blockade. The incidence of adverse side-effects such as sedation and vomiting did not differ statistically and were clinically not significant. This study strongly supports the use of tramadol at wound closure for prevention of postanaesthetic shivering.
我们研究了伤口缝合时给予曲马多是否能预防麻醉后寒战。150例计划接受全身麻醉和手术的患者被随机分组，高剂量组静脉注射2mg.kg(-1)曲马多，低剂量组静脉注射1mg.kg曲马多，对照组静脉注射0.9%生理盐水。高剂量组有2%的患者出现麻醉后寒战，低剂量组为4%，对照组为48%（与曲马多组相比，p<0.001）。神经肌肉阻滞逆转后气管拔管没有延迟。镇静和呕吐等不良反应的发生率在统计学上没有差异，临床上也不显著。这项研究有力地支持了在伤口缝合时使用曲马多预防麻醉后寒战。
